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REVIEW ARTICLE
Year : 2018  |  Volume : 6  |  Issue : 3  |  Page : 35-39

Granulomatous diseases: An updated review


1 Oral Medicine and Radiology, V. S. Dental College and Hospital, Rajiv Gandhi University, Bengaluru, Karnataka, India
2 Oral Medicine and Radiology, 3D Digital Dental Design, Rajiv Gandhi University, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Amirneni Sailaja Choudary
V.S Dental College & Hospital, K.R Road. V.V Road, Bangalore, Honey Dew Apartment, 4th Cross, Venkatadri Layout, J. P. Nagar, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/INJO.INJO_5_18

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Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by genetically heterogeneous conditions, characterized by recurrent, life-threatening bacterial and fungal infections, and granuloma formation. The genetic defect in any of the five subunits of the nicotinamide adinine dinucleotide phosphatase hydrogenases oxidase complex is responsible for the respiratory burst in phagocytes. Patients with CGD are at an increased risk of life-threatening infections with catalase-positive bacteria and fungi and inflammatory complications such as CGD colitis. The implementation of routine antimicrobial prophylaxis and the advent of azole antifungals have considerably improved their overall survival, life expectancy remains decreased compared to that of the general population.


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